Valproic acid-induced hyperammonemic encephalopathy in a patient receiving valproic acid monotherapy
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چکیده
منابع مشابه
Valproic acid-induced hyperammonemic encephalopathy: MR appearance.
Valproic acid currently is used as an anticonvulsant medication with a broad spectrum of activity. It usually is used in seizures in children and adults that are not controllable by other anticonvulsants. A documented side effect of valproic acid therapy has been the elevation of the serum ammonia level , with the subsequent development of hyperammonemic encephalopathy. We report the brain magn...
متن کاملValproic Acid-induced Hyperammonemic Encephalopathy Promoted by Levetiracetam
Encephalopathy resulting from the administration of levetiracetam (LEV) is a rare occurrence. We experienced a patient receiving LEV treated with valproic acid (VPA) for partial seizures with secondary generalization, following which she developed hyperammonemic encephalopathy and showed complete recovery after the drug was withdrawan. LEV is able to promote hyperammonemic encephalopathy when a...
متن کاملValproic acid induced hyperammonaemic encephalopathy.
OBJECTIVE To observe clinical and laboratory features of valproic acid-induced hyperammonaemic encephalopathy in patients taking valproic acid. METHODS Observational study was conducted at the Neurology Department, Dow University of Health Sciences, Civil Hospital, Karachi, from February 26, 2010 to March 20, 2011. Ten patients on valproic acid therapy of any age group with idiopathic or seco...
متن کاملHyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction
Valproic acid-induced hyperammonemic encephalopathy is a rare yet serious adverse drug reaction. Medication interactions such a valproic acid and topiramate can precipitate an event. We present the case of a 52-year-old female that presented with acute mental status change and hypersomnolence due to hyperammonemia caused by a valproic acid derivative. The patient improved after withdrawal of th...
متن کاملValproic-induced Hyperammonemic Encephalopathy in a Known Case of Epilepsy
Valproic acid, a broad-spectrum anticonvulsant drug, commonly causes elevated ammonia levels, which is usually asymptomatic in most cases. On rare occasions, potentially fatal hyperammonemia-induced encephalopathy can occur. We present a case of a 24-year-old female who presented to the emergency department with status epilepticus that was being managed with valproic acid. Further workup was do...
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ژورنال
عنوان ژورنال: Rinsho Shinkeigaku
سال: 2019
ISSN: 0009-918X,1882-0654
DOI: 10.5692/clinicalneurol.cn-001254